Some recent studies measures the risk/benefit and safety assessment of polyphenol consumption. Contrary to popular belief, taking too much polyphenols (including tea) may not be beneficial but rather harmful as these studies points out to the fact that excessive consumption of tea during pregnancy may be associated with elevated risk of childhood malignancy (Plichart et al (2008), Wang & Jiang (2008)). Besides, Luoise et al (2005) enumerated the carcinogenic/genotoxic effects of polyphenols.
Many of us consume tea/coffee on average of 3-4 cups per day which may not be of great concern. But what about others who take excessive tea without being informed about the harmful effects of polyphenols?
http://ajcn.nutrition.org/content/81/1/326S.full
Dear Colleagues,
Good Day,
I am not specialist in your field, but I found really useful articles/ papers related to the thread, please, see them....
http://ajcn.nutrition.org/content/81/1/326S.full
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274725/
http://www.scielo.br/scielo.php?pid=S1516-89132011000600011&script=sci_arttext
https://books.google.iq/books?id=aILVwQhjsBMC&pg=PA1&lpg=PA1&dq=Are+polyphenols+genotoxic+and+carcinogenic&source=bl&ots=Fv4hLJdMKJ&sig=GP7UjMZk6s_jYqPveiypICfQ7pQ&hl=en&sa=X&ved=0ahUKEwig4vH1vY_KAhXCBywKHV0GBhA4ChDoAQgeMAI#v=onepage&q=Are%20polyphenols%20genotoxic%20and%20carcinogenic&f=false
Dear Sidharta Chatterjee,
In some situations polyphenols may cause and adverse reaction instead of a benefit effect on health. Nonetheless as far as I know the main adverse effects have been reported, in most cases, when polyphenols are ingested in higher doses through dietary supplements; on the other hand, when ingested during consumption of fruits, vegetables, cereals, etc, the metabolic xenobiotic processes of the body are, usually, enough to metabolise and excrete these compounds.
I've put here a few papers that may help you on this subject.
Risks and safety of polyphenol consumption
Louise I Mennen,
Ron Walker,
Catherine Bennetau-Pelissero, and
Augustin Scalbert
Abstract
This article gives an overview of the potential hazards of polyphenol consumption, as reported during the round-table discussion at the 1st International Conference on Polyphenols and Health, held in Vichy, France, November 2003. Adverse effects of polyphenols have been evaluated primarily in experimental studies. It is known, for example, that certain polyphenols may have carcinogenic/genotoxic effects or may interfere with thyroid hormone biosynthesis. Isoflavones are of particular interest because of their estrogenic activity, for which beneficial as well as detrimental effects have been observed. Furthermore, consumption of polyphenols inhibits nonheme iron absorption and may lead to iron depletion in populations with marginal iron stores. Finally, polyphenols may interact with certain pharmaceutical agents and enhance their biologic effects. It is important to consider the doses at which these effects occur, in relation to the concentrations that naturally occur in the human body. Future studies evaluating either beneficial or adverse effects should therefore include relevant forms and doses of polyphenols and, before the development of fortified foods or supplements with pharmacologic doses, safety assessments of the applied doses should be performed.For more plz read at following link.
Have a nice day
http://ajcn.nutrition.org/content/81/1/326S.full
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