I am struggling to find literature clearly exposing the relationship between amino acid contact number and protein stability. In particular, I would like to know if this on average true that mutations of amino acids with a high contact number have more impact on protein stability than mutations at low contact number amino acids. Thanks in advance for your help, as you probably guessed I am very ignorant in this subject.
Proteins with high contact number are likely to be buried in the protein core while those with low contact number are likely to on the surface.
Core mutations on average will be more strongly destabilizing
http://www.sciencedirect.com/science/article/pii/S0022283607004342
Thanks Jeffrey and Julian for your very helpful answers, and sorry for the late acknowledgement. And good luck Julian with your project, it does sound very interesting.
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