I think that the presence of glutathione is one of the very important compounds because it is one of the super antioxidants and has various functions important to the body..

Ali Ibrahim Mohammed Hassan Elbahrawy

Thanks a lot Dr Luay A. Al-Helaly

I am talking about its bioavailability and cell entrance. Does it easily enter the cell and if taken from outside it will be valuable.

Mostly, glutathione will be digested and thus converted to the amino acids that make up it...

Supplementation of glutathione is thought to support this pool of glutathione in a cell and thus maintain the efficacy of the entire glutathione system. Despite the pervasive role of glutathione in cell biology, it currently has a limited role in nutritional supplementation due to the following pharmacokinetic properties:

• There may be some absorption of glutathione intact from the intestines, but it cannot enter cells intact. It must be metabolized to form L-cystine (two molecules of L-cysteine bound together) before being taken up.
• Provision of L-cysteine within the cell is all that is needed to increase glutathione synthesis, and N-Acetylcysteine does this efficiently at a lower financial cost than glutathione.

In effect, glutathione is an indirect and expensive way to provide dietary L-cysteine. Dietary protein itself, including L-cysteine rich sources such as Whey Protein, are effective but inefficient ways to increase L-cysteine intake in the diet and N-Acetylcysteine is both more efficient and cheaper than glutathione.

Ali Ibrahim Mohammed Hassan Elbahrawy

Thanks a lot Dr Luay A. Al-Helaly for you explanation

You are welcome.. Dr Ali Ibrahim Mohammed Hassan Elbahrawy