Parkin protein importaint bıomarker in neurodegenerative disease and this protein has neuroprotectıve effect in neurodegenerative disease and cancer.
This article was about increasing parkin activity, you can check it: Ubiquitination Increases Parkin Activity to Promote Autophagic α Synuclein Clearance - Plos journals.
http://dx.doi.org/10.1371/journal.pone.0083914
According to this study Parkin is also
a means of fighting against TB.
https://www.eurekalert.org/pub_releases/2013-09/uoc--tap090313.php
Regards,
Joachim
The comparative toxicogenomics database is a good starting point for finding chemicals that increase or decrease expression/activity etc.
This links to Parkin data (PARK2)
http://ctdbase.org/detail.go?type=gene&acc=5071&view=ixn
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