The timeline for the history of ALS showing up fits with the discovery of the chickenpox vaccine. I looked up the timeline after watching a documentary series on vaccines and in that series they talk about a study on the measles vaccine and this increase in adult shingles that showed up. They believe that exposure to children with measles serves as an immunity "booster" and without it, the risk of shingle dramatically increases. The other thing that really prompted me to ask is a clinical trial the specifically excludes participation based on chickenpox.
And then I just saw this article about a neurological "nodding disease" http://www.sciencemag.org/news/2017/02/mystery-nodding-syndrome-may-be-triggered-parasitic-worm.
The article is tying in measles as having some responsiblity, but measles and the worm have been around for much longer than this disease showing up, but measle vaccine programs started in the early 90s, https://www.cdc.gov/mmwr/preview/mmwrhtml/mm4827a3.htm
Just not investigated, and I looked into this based on a woman who says her daughter became sickly after having the gardasil vaccine at age 12 and died from ALS at age 25:
AMYOTROPHIC LATERAL SCLEROSIS
Epidemiologic Evidence
No studies were identified in the literature for the committee to evaluate the risk of amyotrophic lateral sclerosis (ALS) after the administration of HPV vaccine.
Weight of Epidemiologic Evidence
The epidemiologic evidence is insufficient or absent to assess an association between HPV vaccine and ALS.
Mechanistic Evidence
The committee identified one publication and one abstract reporting the development of ALS after administration of HPV vaccine. Slade et al. (2009) did not provide clinical, diagnostic, or experimental evidence including the time frame between administration of vaccine and development of symptoms. This publication did not contribute to the weight of mechanistic evidence.
Huang et al. (2009), in an abstract, described a 14-year-old girl presenting with a rapidly progressing motor neuron disease 2 months after administration of the third dose of the HPV vaccine Gardasil. Despite treatment the patient's weakness progressed leading to her death from respiratory failure 23 months after vaccination. Laboratory examinations revealed infiltrates of macrophages and T lymphocytes in the grey and white matter of the spinal cord and demyelination and loss of motor neurons. The patient was diagnosed with a rapidly progressive form of juvenile ALS.
Further investigation revealed that the patient expressed a point mutation in the fused in sarcoma/translocated in liposarcoma (FUS/TLS) gene leading to an amino acid substitution in a highly evolutionarily conserved region of the protein (Huang et al., 2010). Immunohistochemistry staining of motor neurons from the spinal cord revealed strongly FUS-positive basophilic inclusions in the patient. In contrast, patients with lateonset ALS showed no FUS-positive inclusions in motor neurons from the spinal cord. Similar basophilic inclusions were observed in the reticular formation in the medulla oblongata, red nucleus, nucleus ambiguous, sensorimotor cortex, and frontal cortex in the patient.
Based on the genetic analysis and neuropathology, the authors did not attribute the rapidly progressive form of juvenile ALS in the patient to vaccination against HPV using the quadrivalent vaccine Gardasil.1
Weight of Mechanistic Evidence
The symptoms described in the publication referenced above are consistent with those leading to a diagnosis of ALS. Autoantibodies, T cells, and molecular mimicry may contribute to the symptoms of ALS; however, the publications did not provide evidence linking these mechanisms to HPV vaccine.
The committee assesses the mechanistic evidence regarding an association between HPV vaccine and ALS as lacking.
Causality Conclusion
Conclusion 9.8: The evidence is inadequate to accept or reject a causal relationship between HPV vaccine and ALS.
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