Although many studies have been conducted on the immunogenicity of intranasal acellular pertussis vaccines in mice, I didn't find any studies in human clinical trials. Why haven't these studies continued on humans? Is there a reason for this? As far as I know, there are two types of pertussis vaccines, BPZE1 and GAMLPV, in clinical trials, but these are live attenuated vaccines.
Hello dear Yahya
I think the attached article entitled " Mucosal Immunization against Pertussis: lessons from the Past and Perspectives" may help you. Both safety and immunogenicity concerns and challenges of mucosal aPVs such as using the appropriate adjuvant with a simultaneous potential of stimulation of humoral and cell-mediated responses in human has been reported in this article which may answer your question.
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