Determining the protective titre for a vaccine involves assessing the level of antibodies in the blood that provide sufficient protection against the specific live organism or pathogen. The process typically involves the following steps:

The protective titre is generally determined based on statistical analyses of the antibody titres and the outcomes of the live organism challenge. The specific threshold for a protective titre can vary depending on the vaccine and the target pathogen. In some cases, a specific level of antibodies may be associated with a higher probability of protection, while in other cases, a more complex analysis may be required to establish the correlation between antibody levels and protection.

It's important to note that determining the protective titre is just one aspect of vaccine evaluation. Other factors, such as cellular immune responses and the duration of protection, may also be considered in assessing the overall efficacy of a vaccine.

@Saif Wahid

Thanks a lot for your response.

Sir, virus neutralization test can be performed.