I have read a number of previous original research (including some reviews) that analysed the association between metformin use and risk of lactic acidosis.
In almost all studies, the outcome has been zero. However, there are some few case-control studies (and case series) that showed the likely association.
Is there anyone aware of conference abstracts/unpublished data regarding this aspect? Kindly share.
Cheers!
Kelvin,
The association between metformin and lactic acidosis is well described in the literature particularly with diabetic patients that have compromised renal function. I conducted a quick literature search using keywords "lactic acidosis and metformin". I compiled some of the more recent abstracts for you (about 50-60 out of 650 generated). If you send me an email I will send you the compiled abstract file on word document. Alternatively, you can search the same keywords on PubMed and it will generate many recent findings/case reports etc on the topic. Hope this is helpful to your query on metformin.
Best,
Jorge Jacot, Ph.D.
Hi
I second hand what Dr.Jacot mentioned.
I recommend checking the recently published
Abstracts from ATTD 2015 8th International Conference on Advanced Technologies & Treatments for Diabetes, Paris, France—February 18–21, 2015. Available from: https://www.researchgate.net/publication/273696613_Abstracts_from_ATTD_2015_8th_International_Conference_on_Advanced_Technologies__Treatments_for_Diabetes_Paris_FranceFebruary_1821_2015 [accessed Mar 20, 2015.
It contains a huge compilation of recently conducted studies out of which your topic of interest can be found. You can download it from my profile page.
Good luck
Mahmoud Salam, RN, MSN
Conference Paper Abstracts from ATTD 2015 8th International Conference on Adv...
Metformin inhibits cell respiration which cause increasing demand for Anaerobic respiration (increase Lactic acid ) but this occurs when high doses of metformin were used in human and rodents.
thanks all,
Jorge, my interest is on the availability of raw data that shows the association between the 2 named entities.
I have read hundreds of articles on the subject. However, almost all of them failed to establish whether the association was meant to be causal. They just highlighted a linear relationship that can be confounded by a handful of other known and unknown variables.
Until now, I have failed to establish whether the association declared was caused by metformin treatment (remember, diabetes as a syndrome can cause lactic acidosis, all other factors in check) or a coincidence due to some other known/unknown factors.
Likewise, there have been conflicting results on the relative contraindications of metformin Rx to the elderly population. Be aware there are several guidelines warning metformin use to people of 80 years and above. It is not clear whether that warning has anything to do with age as a factor or originating from an increased likelihood of renal or hepatic functional failure in that age category. By saying so, I do believe the concept of checking for renal and hepatic functions before prescribing metformin to diabetics to be universal and across all age groups.
It is therefore not logical to deny an an obese diabetic octagenarian a prescription of metformin (especially if he/she has 'acceptable' values on renal and hepatic functional tests) based on what appears to be anecdotal description.
Otherwise, to get a clearer picture of why I asked this question, kindly find attached articles warning clinicians against "unfounded" risk of developing lactic acidosis from administration of metformin.
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