Any resource showing circRNA (circular RNA) sponging (trap) mRNA?

06 March 2023 1 10K Report

Hi all,

I am looking for some resources showing sponging/trapping mRNA? Most of the papers about sponge function of circRNA show only miRNAs or proteins (RBB)/peptides etc. I need specifically for mRNA. Thanks

Best,

Sherif Ibrahim

The "mRNA trap" by circRNA does not mean it binds mRNA. Instead, this is an expression used to describe a process in which a non-translatable circular RNA is formed as an alternative splice to the translatable mRNA. This is a possible way of regulating the expression of the mRNA and the protein it codes. it could be also called alternative circularization.

I described this process in my review article:

https://www.hindawi.com/journals/omcl/2021/6634601/

You can also there refer to the original articles that described the process

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