AMPK isoforms are connected with type I, IIa, IIx isoforms of muscle fiber. Type IIx has a higher ratio of gamma 3 AMPK, how can this be seen ?
AMPK has a role is cell energy metabolism. Could it be that some isoforms would promote fatty oxidation, while for instance gamma 3 AMPK would lift up the energy content (amp/atp) through glycolysis (in relation to others who would also focus more on fatty oxidation?)
Type IIx is intermediate between type I and IIb fibers, they have intermediate numbers of mitochondria and oxidative potential resulting in moderate strength and improved resistance to fatigue , and usually considered as less oxidative than type I fibers in term of metabolic profile, have either higher or similar PGC-1α content compared to type I fibers.
References
Duan Y, Li F, Wang W, Guo Q, Wen C, Yin Y. Alteration of muscle fiber characteristics and the AMPK-SIRT1-PGC-1α axis in skeletal muscle of growing pigs fed low-protein diets with varying branched-chain amino acid ratios. Oncotarget. 2017;8(63):107011-107021. doi:10.18632/oncotarget.22205.
Gouspillou G, Sgarioto N, Norris B, et al. The Relationship between Muscle Fiber Type-Specific PGC-1α Content and Mitochondrial Content Varies between Rodent Models and Humans. Schuelke M, ed. PLoS ONE. 2014;9(8):e103044.doi:10.1371/journal.pone.0103044.
- Badges
- Science topic
- Similar topics
- Medicine
- Physiology
- Biosignals
- Biomedical Signal Processing
- Statistical Analysis