What are the best candidate molecules for in vivo radiotracer (PET) imaging of aggregated alpha-synuclein? Are anybody aware of candidate small molecules, antibodies or small peptides which have been successfully labeled with radio-isotopes and tested in e.g. animal models or post mortem human brain tissue and shown promise (i.e. specificity for alpha-syn over beta-amyloid and tau protein)?
As far as I know to date there are no validated methods to look at alfa synuclein in living brain. In fact there is a project of the Michael J Fox foundation launched for this purpose.
I attach a link from MJF Foundation website for your information.
https://www.michaeljfox.org/foundation/news-detail.php?alpha-synuclein-imaging-consortium-publishes-first-paper
Today i found a videi through JOVE which is entitled with "Bioluminescence Imaging of Neuroinflammation in Transgenic Mice After Peripheral Inoculation of Alpha-Synuclein Fibrils". i attached the link may it would be helpful for you.
Breid, S., Bernis, M. E., Tachu, J. B., Garza, M. C., Wille, H., Tamgüney, G. Bioluminescence Imaging of Neuroinflammation in Transgenic Mice After Peripheral Inoculation of Alpha-Synuclein Fibrils. J. Vis. Exp. (122), e55503, doi:10.3791/55503 (2017).
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