M. Sardina

3 Questions 44 Answers 0 Followers

Questions related from M. Sardina

What's your opinion on assay sensitivity (i.e. placebo arm) in asthma trials?

Could placebo be accepted from an ethical point of view for short term studies (e.g. 8 weeks)? Which alternatives are there? E.g. low fixed dose of inhaled corticosteroid.

02 April 2014 2,870 8 View

What is the expected variability, between trials of the same product in control of motor fluctuations (ON/OFF) in advanced Parkinson Disease?

Which results on motor fluctuations for add on therapies to L-Dopa and which consistency/variability between multiple trials with the same product in the same population.

21 March 2014 645 4 View

What is the threshold amount of sorbitol in an oral formulation affecting the bioavailability of the active principle?

Sorbitol is an excipient used for oral formulations and it is generally know to affect drug bioavailability. However it is not known if there is a threshold.

12 February 2014 1,806 0 View