Hello Muhammad Arif Afridi

My first guess would be student t-test but would be most happy to hear if you - or anybody else - thinks this view is too simplistic.

Great topic very interesting

You can do Roc curve to assess the diagnostic performance for the two.

If the experimental design will be recording a significant amount of false-negative and false-positive observations, then the ROC will have a big advantage over the student t-test.