can you help me? I am not sure that whether there are some distinctions between the severity and the activity of UC in patients, which are usually assessed by the Truelove & Witt Activity Index and the mayo index respectively. Thanks very much!
Disease activity in UC is evaluated using both clinical and endoscopic features.
Modified Mayo score and Trulove-witts are mostly used for clinical evaluation of activity.
The most commonly used scoring system for endoscopic disease activity is the Mayo score. However Rachmilewits is also exercised for endoscopic activity score in UC.
Disease activity means that inflammation is present, it could be measured by clinical and endoscopic scores (like the Mayo score). Severity is just the grade of inflammation. To be practical: a patient can have no inflammation (no activity) or inflammation (disease activity), that can be mild, moderate or severe (severity of disease).
In clinical, whether can we use Trulove-witts to evaluate the activity of UC to some extent?
in other words, bothTrulove-witts and Mayo can assess the activity of UC In clinical.
Diease activity can be assessed by endoscopic or clinical criteria. There are several clinical and endoscopic classifications. Among the most used clinical scores is the Truelove - Witts, which classifies the patient according to the disease severity, into remission, mild, moderate or severe activity , according to parameters such as pulse rate, frequency of bloody stools, among others. The Mayo score is an endoscopical index showing the degree of inflamation in the mucosa. A patient can be, for example, in CLINICAL remision but in a mild endoscopic activity.
Mayo score consists of four items including the endoscopic subscore. The Mayo score without the endoscopic subscore is based on both symptoms and Physician Global Assessment. The Mayo score is the most used score i daily Clinical Care and Clinical trials. The endoscopic inflammation is evaluated endoscopically by Mayo endoscopic subscore, the ulcerative colitis endoscopic index of severity (UCEIS) or some other index. Many different score indices exist, most are poorly validated.
http://www.ncbi.nlm.nih.gov/pubmed/11832465
The disease activity index (DAI) of ulcerative colitis was marked in regard to the weight loss, blood in the stool and stool consistency.
reference: (K.W. Schroeder, W.J. Tremaine, D.M. Ilstrup, Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis, N. Engl. J. Med. 317(1987) 1625–1629,)
it is suggested that inflammation extension in colonoscopy and histological manifests were analyzed based on the Montreal Classification for the confirmation of UC.
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