In case of beta+, where less severe mutation occurs, can HbD and HbE variant can produce some good but reduced beta chains?
If this is a research question, check the literature for case studies.
If this is a homework question, same reply.
If both 'Hb D' and 'Hb E' detected are really beta-globin chain mutants and not any other alpha chain variant, Hb A (alpha2-beta2) can not be there.
It may depend on the method of measurement of the variants. Ramesh Z. Patel is right for all cases detected by electrophoresis because then both beta chains will have one mutation. If measured by direct detection of the mutation then there may be rare cases where , for example, a HbD carrier also has the HbE variant on the same chromosome either by crossover or a new mutation but this seems very unlikely
In Hb T Cam
bodia, both the mutations (of Hb E and Hb D) are on same beta gene, but it will not give two bands of Hb E and Hb D; instead there will be a single variant band cathodal to Hb A2.
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