Phagocytosis by phagocytic cells is a crucial part of the host defense against invading microorganisms once the outer epithelial surface of the body has been breached. The most important cell types involved are polymorphonuclear leukocytes (PMNs) and mononuclear phagocytes (MNs; monocytes and macrophages), both of which are derived from precursor cells in the bone marrow.

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