Hi everyone,
I have 1.5 mL eppendorf tubes with nanoparticle pellets in water (ZIF8, UIO-66 and UIO-66-PEG). No matter how hard I try to homogenise them into single nanoparticles, using pipetting up and down and vortexing, they immediately clump into a pellet. Do you think that if I put an eppendorf tube with these NPs into a waterbath sonicator, it would be possible to break these clumps into single NP-solution without forming clumps?
Would the walls of eppendorf tube absorb the sonic waves and therefore prevent efficient nanoparticle homogenisation?
Thanks,
Kind regards,
Maria
Yes, sonication can be used to break down the clumps of nanoparticles into single NP-solutions without forming clumps. Sonication creates rapid, high-energy sound waves that cause cavitation in liquid, resulting in a very effective form of homogenization. When done carefully and at the proper duration, sonication can break down larger particles into smaller particles, which reduces the size of the aggregates and prevents clumping of the nanoparticles.
Dear R. Sagayaraj Dr. Sagayaraj, Thank you for your recommendation. I will try sonication.
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