Although PCR and NAH techniques proves that latent VZV exists in central ganglia, it cannot be isolated from human ganglia. What (camouflage) mechanism does the herpes VZV adopt to avoid detection in living humans? What is the mechanism of this "dormancy"?
Thanks Dr. Thilo for your answer.
Well as you have mentioned, it is apparent that there are no virions produced in latent stage, and so no detectable mi RNA , but I assume it may be also due to the fact that the latent virion is too labile to be isolated. Also, there is evidence that the histone-associated virus genome assumes a circular episomal configuration and the lack of animal model makes it difficult to isolate the latent phase of VZV from the ganglia cells. However, there may be novel methods developed to isolate high titre cell-free viral extracts from the latent stage in future.
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