Although gall bladder and bile ducts are lined by similar biliary epithelium, what is the reason for such a aggressive behavior and biology of gall bladder cancer as compared to cholangiocarcinoma?
Essentially they are different epithelium, even grossly appearing so.
In the pancreatico biliary system, there are at least 4 distinct epitheium:
Our characterization of them morphologically seems simplistic at best, and one could expect additional division in the future.
Yeaton P, Kiss R, et al. Multiparameter digital image analysis of biliary, ampullary and pancreatic adenocarcinomas. Modern Pathol 1995;8:843-7
It remains an old story, as yet untold
Good explanation and description by Dr ossama and Paul.In clinical practice what has been noticed with GB carcinoma is late presentation or non specific symtoms.This delays the diagnosis.In addition silent aggresive behaviour.Some of the patients in this part of the world tend to postpone chlecystectomy as stones are more often associated.
where as CCA is some what different,not that it carries any better prognosis.
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