Total Antioxidant Capacity (TAC) indicates the ability of the body to combat oxidative stress. In my work with patients suffering from Chronic Kidney Disease, TAC values are found to be low in patients in initial stages of CKD. But surprisingly the TAC values are found to be higher than controls in advanced stages (CKD stage 4 &5). Could the uremic status contribute to this increase?
It is relatively due to high serum urate. You may observe the reduction of major chain-breaking antioxidants after dialysis. Although urate is an efficient antioxidant they are not able to provide an adequate antioxidant defense if there is a deficiency of other antioxidant systems. Therefore, we need to measure the major chain-breaking antioxidants individually in addition to total antioxidant capacity.
Are you measuring the TAC of the blood serum? If so note that it's difficult to translate these data to events taking place in the kidney during CDK due to the fact that ROS and ROS-scavenges plays crucial role inside the tissue. Some of ROS (H2O2 for ex.) have enough lifetime to serve as signal molecule through the systemic circulation, but such mechanisms are still disputable. Good luck!
Yes...I am measuring TAC in blood of subjects in various stages of CKD and also in that of controls(no CKD) before and after treatment of periodontitis. Values of TAC in initial stages of CKD are lower than that of controls but subjects on hemodialysis show higher values of TAC. After periodontal treatment, parameters of oxidative stress show improvement across all stages but TAC values in Dialysis patients continue to be higher.
As oxidative stress is associated with CKD pathogenesis, we have to consider interplay between ROS and ROS-scavenging enzymes, which has generally dynamical: https://www.researchgate.net/publication/272842066_Active_ribosomal_genes_translational_homeostasis_and_oxidative_stress_in_the_pathogenesis_of_schizophrenia_and_autism
Article Active ribosomal genes, translational homeostasis and oxidat...
Uric acid is high in CRF (lack of nephrons to filtrate and secrete it) and uric acid is a main component of TAC.
But, be careful, uric acid at high values can become a prooxidant!
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