Is there any way to find the biological correlation between miRNA and genes?

We are trying to find the biological correlation between miRNA and certain genes. We found the general correlation through IPA (Ingenuity Pathway Analysis). Thank you for your inputs!

05 June 2019 6,900 6 View

Please suggest how should i approach for removal of UMI sequence?

I have mi-RNA sequencing data, where my 3 prime adapter is attached with 12 Nucleotide UMI Sequence (in random manner) along with Reverse Transcriptase primer and Universal Adapter Overall...

31 December 2018 561 5 View

How to merge trajectories after extending simulations in desmond?

I found an explanation in Schrodinger's knowledge base but i am not sure how to run the python scripts in Ubuntu. If possible kindly suggest an easy way. Huge Thanks

08 September 2018 7,715 3 View

Transcription factor binding and expression?

I have a transcription factor protein X and X has a co-activator protein Y. XY bind to the DNA and downstream expression of proteins occur. Now I block the activity of X through inhibitor but dont...

07 August 2018 6,370 7 View

Help with Desmond simulation graph?

Kindly help me interpreting the graph. I am not sure if the ligand is still intact with protein or it has diffused away.

06 July 2018 1,949 6 View

How to carry out membrane protein and peptide simulations?

I want to study the dynamics of ABC transporters along with a peptide molecule which in physiological conditions passes through the transporter. I am clueless how to set the peptide molecule in to...

05 June 2018 6,043 5 View

Help with GROMACS .mdp file parameters?

Hello awesome people, I am new to GROMACS and i have been practicing with different tutorials available online. I successfully ran 1ns simulations. I ran couple of simulations with mdp files as...

01 February 2018 3,515 4 View

Are these normal in Gromacs?

I have following doubts in Gromacs ,and want to know if these things are normal? or i am doing something wrong? 1) The protein is outside the solv box ( picture 1). 2) while i am running...

01 February 2018 7,721 5 View

Software that can find active site itself and dock the protein?

I want to perform protein-protein docking .Please suggest me some software's which can find active site by itself and dock the protein. I have tried HADDOCK but u need to provide active sites in...

08 September 2017 4,589 3 View

Problem with PDB file?

08 September 2017 9,899 8 View

Do we need to write protocol for a second study of a systematic review that has been registered and published?

I have conducted and published a systematic review and meta-analysis research with the topic related to public health and health pomotion (protocol was registed in PROSPERO). Now we want to...

03 March 2021 8,920 3 View

Ideas for Phd's Thesis on pricing (Marketing)?

Hi everyone, I'm studying Marketing and I would like to write my PhD thesis on the topic of pricing. Any specific ideas?

02 March 2021 9,706 5 View

Gel electrophoresis result for total RNA samples, 1.5 Agarose gel was used, How to improve the integrity of RNA?

Gel electrophoresis, RNA degradation, RNA extraction from fresh tissue

02 March 2021 5,433 5 View

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02 March 2021 3,060 3 View

How to write a scientific report?

We are analysing scientific reports at University in great detail, so I wanted to find a scientific report about how to write a scientific report. Including detail such as what information to put...

02 March 2021 7,602 4 View

New Journal, "Integrative Psychological and Behavioral Science" -- do you not know, and have you not seen, this done before?

Question to you and THEM, the New Journal, "Integrative Psychological and Behavioral Science" -- do you not know, and have you not seen, this done before? There appears to be a core problem for...

02 March 2021 3,024 2 View

Could any one guide me, to write research proposal for grant? ?

We have one plant, the local people using this for controlling blood sugar, the toxicity and antidiabetic activity of the plant is not reported yet, please guide from whag should be the process ?...

02 March 2021 2,300 1 View

Energy minimization in LAMMPS using NVT ?

How do I do energy minimization in lammps with NVT ensemble ? I am using the following command and it does not seem to work. It stops at extremely high energy and gives me the error zero search...

01 March 2021 2,294 3 View

No title

01 March 2021 3,905 5 View

How to Balance Bench work with Reading and Writing?

I am a second-year grad student. I am finding it difficult finding time to read literature and write (things like qualifying exam, thesis, grants). I find myself so busy with bench work that I...

01 March 2021 3,325 4 View