Why develop conditional KO mouse including both tissue-specific and inducible mouse?

10 October 2017 0 7K Report

A tissue-specific Knockout mouse defines a conditional biological model in which a target gene can be specifically inactivated in specific tissue(s); in all other tissues, the target gene exhibits a functional expression.

An inducible Knockout mouse defines a conditional biological model in which the target gene of interest can be specifically inactivated at a given time point. Before induction, the gene of interest is functionally expressed. Inactivation can be engineered in all cells of the body or in a tissue-specific manner.

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