Why is intravenous injection a kind of systemic drug delivery (what areas cannot this injection method reach when we deliever drug/virus and what else other methods that could help drug/virus to reach all parts in body especially going to nerve system and brain)?
IV is a systemic delivery because it is delivered into the systemic circulation. To reach the CNS it is dependent on the nature of the molecule, especially on their logP to pass the BBB. Literature study show that the best range of logP(DpH 7.5) is between 1 and 2.
Dear Wei Li,
Actually I didn't get your question. However, regarding drug delivery to the brain, perhaps this article may help you:
Penetration of Drugs through the Blood-Cerebrospinal Fluid/Blood-Brain Barrier for Treatment of Central Nervous System Infections
https://cmr.asm.org/content/23/4/858
Good luck!
IV is a systemic delivery because it is delivered into the systemic circulation. To reach the CNS it is dependent on the nature of the molecule, especially on their logP to pass the BBB. Literature study show that the best range of logP(DpH 7.5) is between 1 and 2.
I think the ability of drug to cross the blood brain barrier is more important than the site of injection
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