Drug-induced Apoptosis in Hepatoma Cells Is Mediated by the CD95 (APO-1/Fas) Receptor/Ligand System and Involves Activation of Wild-type p53

Martina Müller,* Susanne Strand,* Hubert Hug,

‡

Eva-Maria Heinemann,* Henning Walczak,

§

Walter J. Hofmann,

i

Wolfgang Stremmel,* Peter H. Krammer,

§

and Peter R. Galle*

*

University Hospital, Department of Internal Medicine IV, Hepatology and Gastroenterology, Bergheimerstr. 58, 69115 Heidelberg, Germany;

‡

Center of Molecular Biology, 69120 Heidelberg, Germany;

§

German Cancer Research Center, Tumor Immunology Program, 69120 Heidelberg, Germany; and

i

Institute of Pathology, 69120 Heidelberg, Germany