Which pH does disulfide bond form preferably, high pH (~8) or low pH (~6)?

02 February 2018 1 7K Report

which pH does disulfide bond form preferably, high pH (~8) or low pH (~6)?, between the protomer of a dimeric protein?

Thanks.

"Disulfide bond formation is usually favored at basic pH, and the presence of an oxidizing agent such as oxidized glutathione increases the rate of oxidative folding, whereas the presence of denaturants such as urea or guanidine hydrochloride (Gdn.HCl) hampers the folding process. "

from 2012

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