In our pain center we use a five days subcutaneous protocol with 100mg/24 hours.
it sometimes gives good results but also sometimes the situation remains unchanged.
Your opinion interests me, thanks.
In our pain center we use also at home a five days subcutaneous protocol with 0.5mg/kg/24 hours, 2 days stop, and start again 3 week along.
If it does not work, another test with 1 mg/kg/24 hours
Hi, if the first infusion doesn´t work, I will recomend to stop ketamine and try another adyuvant medication. Usually, a standardized titration of the opioid could give better results with similar adverse effect profile. Best regards
Firstly ketamine does not work in the patient who is tissue magnesium depleted. Therefore oral 1 week or IV 24 hours loading with Magnesium is required first.
Best results are combining with Clonidine which usefully also blocks the ketamine induced tachycardia and hypertension.
Generally higher doses produce better results ie 40mg/hour but one has to titrate up slowly to have patients tolerate that.
Even so I find only 1/4 patients benefit from this advanced protocol treatment
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