Is there any alternate animal model for type II collagen induced arthritis in DBA/1 mice? DBA/1 mice is not available easily and thus suggestion on any preferred animal model for the study is invited...
Collagen-induced arthritis in rats is associated with inflammatory polyarthritis, sharing clinical and pathological features with those of human rheumatoid arthritis (RA). Described in this unit is a protocol for consistently inducing arthritis in female Lewis rats by immunizing them with bovine type II collagen (CII) emulsified in complete Freund's adjuvant. This model is of value not only in defining the underlying pathogenesis of RA, but also as a tool for evaluating pharmacological strategies for treating this condition.
Current protocols in pharmacology / editorial board, S.J. Enna (editor-in-chief) ... [et al.] (2008)Volume: Chapter 5, Issue: December, Pages: Unit 5.51