I want to inhibit colon cancer growth with gene therapy in mice, some articles have shown that combining with some inhibitors will raise the efficiency of therapy. Because of this reason, I want to learn the best inhibitors against colon cancer cells.
Check the list of FDA approved drugs for colon cancer. You can start with multiple drugs which are currently in clinical trials for colon cancer. Check out clinicaltrial.gov.
Screen around 5 to 10 drugs.
Check the list of FDA approved drugs for colon cancer. You can start with multiple drugs which are currently in clinical trials for colon cancer. Check out clinicaltrial.gov.
Screen around 5 to 10 drugs.
I would like to recommend the drug to affect the prevention of ROS accumulation in epithelial tumor cells. Colon adenocarcinoma cells generally depend on CD44v-xCT-GSH system to exhibit robustness against redox stress in the tumor microenvironment. That is why the inhibitors are seemingly promising which alter the alternative splicing manner of CD44 from CD44 variant to CD44 standard. However, ESRP1, the main regulator of CD44 splicing, influences on FGFR2, p120 etc, so that side effects are likely to happen after administration of the inhibitor of ESRP1. By striking contrast, sulfasalazine, the conventional drug for rheumatoid arthritis, attracts much attention these days because of its inhibitor affect against xCT-mediated GSH synthesis.
Of course the best choice for combination with gene therapy or siRNA therapy is a well established chemotherapy drug such as Cisplatin, Doxorubicin, docetaxel, and even recently Cytochalasin D. Check the articles below..
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