By applying microarray technologies, we can get a large number of genes at one time. We are working on generating some rule based systems for cancer diagnosis. But first of all, we need to know, from the biological aspects, generally, which genes are the most important genes?
Bernhard Biersack
Mutations in the ras gene occur in 40-50% of colon and lung carcinomas. Myc amplifications and Her2 overexpression also occur frequently in colon cancers.
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Bernhard Biersack
There are some papers about it. Well, I recently gave a talk on the therapy of Ras-mutated cancers. COX-2 levels are also usually increased in colon cancers in contrast to normal colon tissues.
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Axel Grothey
Take a look at the recent publication of the TCGA (The Cancer Genome Atlas) in Nature.
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