Which gene ontology has to be considered while performing semantic similarity?

05 May 2017 1 1K Report

Presently, there are many methods to calculate functional similarity (semantic similarity) between the genes. But there are three domains associated with any gene i.e., Molecular Function (MF), Biological Process (BP) and Cellular Component (CC).

When performing functional similarity what domain has to be considered? Why?

Julio Raúl Fernández Massó

As you are looking for function similarity you should use Molecular Function (MF) or look for the presence of similar domains in the proteins.

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