I observed hexagonal and pentagonal lining structures. I am not sure about the exact location of the RECA. Does it refer to the endothelial cells in the endoneurium?
Well, a picture will help to see what it is. RECA-1 should be endothelial, yes.
Resveratrol Prevents Age-Related
Memory and Mood Dysfunction with
Increased Hippocampal Neurogenesis
and Microvasculature, and Reduced
Glial Activation
Maheedhar Kodali1,2,3*, Vipan K. Parihar4*{, Bharathi Hattiangady1,2,3,4, Vikas Mishra1,2,3, Bing Shuai1,2,3,4 & Ashok K. Shetty1,2,3,4
1Institute for Regenerative Medicine, Texas A&M Health Science Center College of Medicine at Scott & White, Temple, Texas, USA, 2Research Service, Olin E. Teague Veterans Affairs Medical Center, Central Texas Veterans Health Care System, Temple, Texas, USA, 3Department of Molecular and Cellular Medicine, Texas A&M Health Science Center College of Medicine, College Station, Texas, USA, 4Department of Surgery (Neurosurgery) and Research Service, Duke University and Veterans’ Affairs Medical Centers, Durham, North Carolina, USA.
Greatly waned neurogenesis, diminished microvasculature, astrocyte hypertrophy and activated microglia are among the most conspicuous structural changes in the aged hippocampus. Because these alterations can contribute to age-related memory and mood impairments, strategies efficacious for mitigating these changes may preserve cognitive and mood function in old age. Resveratrol, a phytoalexin found in the skin of red grapes having angiogenic and antiinflammatory properties, appears ideal for easing these age-related changes. Hence, we examined the efficacy of resveratrol for counteracting age-related memory and mood impairments and the associated detrimental changes in the hippocampus. Two groups of male F344 rats in late middle-age having similar learning and memory abilities were chosen and treated with resveratrol or vehicle for four weeks. Analyses at ,25 months of age uncovered improved learning, memory and mood function in resveratrol-treated animals but impairments in vehicle-treated animals. Resveratrol-treated animals also displayed increased net neurogenesis and microvasculature, and diminished astrocyte hypertrophy and microglial activation in the hippocampus. These results provide novel evidence that resveratrol treatment in late middle age is efficacious for improving memory and mood function in old age. Modulation of the hippocampus plasticity and suppression of chronic low-level inflammation appear to underlie the functional benefits mediated by resveratrol.
Insulin-Like Growth Factors, Angiopoietin-2, and Pigment Epithelium–Derived Growth Factor in the Hypoxic Retina
Journal of Neuroscience Research 86:702–711 (2008)
Duijvestijn AM, van Goor H, Klatter F, Majoor GD, van Bussel E, van Breda Vriesman PJ. 1992. Antibodies defining rat endothelial cells: RECA-1, a pan-endothelial cell-specific monoclonal antibody. Lab Invest 66:459–466.
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