Dear Rengwei,

The following link contains a comprehensive study on OSIMERTINIB which includes chemical and physical properties, pharmacology, pharmacokinetics, toxicity and etc.

Regarding possible impurities (taken from the report): 

Impurities

Four potentially mutagenic impurities (based on structural alerts from commercial databases, DEREK and Leadscope, and/or an in-house database) were evaluated for bacterial mutagenicity in vitro using the Ames assay. Two impurities were negative in Ames assays, and are considered as non-mutagenic whilst the other two tested positive and are considered mutagenic.

Other studies

Osimertinib showed no evidence of phototoxic potential in an in vitro cytotoxicity assay conducted in the presence and absence of UV light.

http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/human/004124/WC500202024.pdf

Hoping this will be helpful,

Rafik

Glad to receive your message and many thanks for your warmhearted answer, nevertheless I've noticed this 134-page report earlier by searching engine,a second view on this report gives me a better understanding :)

yes we can

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