Rengwei Sun

4 Questions 4 Answers 0 Followers

Questions related from Rengwei Sun

What factors may cause racemization in acidic removal of Boc?

I am working on a chiral N-Boc-3-heteroarene(imidazole derivative) substituted piperidine derivative, and we observed a slight drop of optical purity after removal of the Boc in HCl/dioxane(2M)....

19 October 2023 4,449 1 View

How to reduce nitriles into primary amines on HETEROATOM CONTAINING rings?

I am currently trying to achieve the reduction of cyano group into primary amines. A brief review of literatures indicate that H2 /Pd/C or H2 /Raney Ni was most used, however usually with extra...

15 December 2017 2,336 3 View

Is solvent signal supression acceptable in 1HNMR edit ?

During my research, I've prepared some volatile low molecular weight product. Unfortunately,after FCC and removal of the solvent, the 1HNMR sample still consist of impurities (mainly H2O, DCM,...

16 July 2016 8,766 4 View

Where could I get impurity of OSIMERTINIB? or production standard for OSIMERTINIB?

I've consulted USP and EP for the newly approved EGFR inhibitor OSIMERTINIB, but little related information can I get there.

21 June 2016 5,979 3 View