In 2024, which one is the most significant target for CRC drug discovery?
Hello Md.Abid Hassan,
The following would be the most significant targets as per my knowledge.
APC
BRAF
KRAS
NTRK
RET
You may include two more to the above list.
1. Pleckstrin 2
Ref:
https://www.spandidos-publications.com/10.3892/mmr.2021.12502
2. PDE5A
https://www.gastrojournal.org/article/S0016-5085(19)41109-8/fulltext
You will obtain some more potential drug targets from the articles attached below.
https://www.research.ed.ac.uk/en/publications/identification-of-novel-protein-biomarkers-and-drug-targets-for-c
https://www.sciencedirect.com/science/article/abs/pii/S0925443923002466?via%3Dihub
Best.
Some work on HDAC as option for treatment of colorectal cancer in vivo it show accepted result but not the case in vitro.
Vorinostat show response for crc but not in vitro.
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