Hello Md.Abid Hassan,

The following would be the most significant targets as per my knowledge.

APC

BRAF

KRAS

NTRK

RET

You may include two more to the above list.

1. Pleckstrin 2 

Ref:

https://www.spandidos-publications.com/10.3892/mmr.2021.12502

2. PDE5A 

Ref:

https://www.gastrojournal.org/article/S0016-5085(19)41109-8/fulltext

You will obtain some more potential drug targets from the articles attached below.

https://www.research.ed.ac.uk/en/publications/identification-of-novel-protein-biomarkers-and-drug-targets-for-c

https://www.sciencedirect.com/science/article/abs/pii/S0925443923002466?via%3Dihub

Best.

Some work on HDAC as option for treatment of colorectal cancer in vivo it show accepted result but not the case in vitro.

Vorinostat show response for crc but not in vitro.