Hello everyone,
What will occur if we do partial hepatectomy in rat or mice then transplant the excised part in omentum (autotransplantation)? Will the transplanted part be functional (decrease ALT and AST) or it will be enzymatically degraded?
We transplant the excised native liver after partial hepatectomy into the omentum of the same animal (5x5x2-3mm). So, will the function back to normal again because of transplanted part compared to just partial hepatectomy (control group)?
Thank you in advance!
Dr. Hussein,
my experience with intraomental transplantation of various tissues taught me that tissue fragments up to 5 mm can survive until some angiogenesis occurs (3-4 Days). However, I did not do think this will decrease AST or ALT as these will be degraded naturally. Tissue degradation will occur thourgh ischemia and/or necrosis and inflammation not enzymatically. Hard to quantify the function of this transplanted tissue as initially it will not support the animal - that will be done by the remnant tissue which will grow in its turn. Histology may be needed.
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