I am working on cancer and molecular markers. I tried to find out which was the first marker identified for cancer, who discovered it and where was it published?
since 1940s biomarkers research have been interestingly increasing, first discovered was the alpha-fetoprotein in 1956 by Bergstrand and Czar but Yuri Semenovich Tatarinov was the Russian scientist who first published antigen specific for human hepatocellular carcinoma in 1963.
Ableve's papers were published in
Abelev, G. I. (1971), Adv. Cancer Res. 14 1295.
Abelev, G. I. (1975), Trans. Rev. 20 3.
Abelev, G. I., S. D. Perova, N. I. Khramokova, Z. A. Prostnikova, and I. S. Irin (1963), Transplant 1 1974.
Czar's paper
Bergstrand C.G. and Czar B. 1956, Scand. J. Clin. Lab. Invest., 8, 174-179
Hi Sangeet,
The first genetic cancer marker identified was t(9;22)(q34.1;q11.2). Publication date is 1960 by Peter Nowell and David Hungerford. Science. 132 (3438): 1497. This is the Philadelphia chromosome, diagnostic for chronic myelogenous leukemia.
The first oncogene discovered was src in 1970 but not named src till later. Martin GS. (1970). Nature, 227, 1021–1023
Hope this is helpful.
thank you, Dr. Burns. This was a wonderful information. I could not find it in the web. Thank you for your reply
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