I want to know whether cancerous or normal cells have the greater contribution in the production of aromatase.
From what I read,practically any kind of cells, from brain to skin have this enzyme for the conversion of androgens to estrogen, that have protective effects. So, probably for this reason for breast cancer it has been decided to target the receptor with tamoxifene
It is a complex play of many factors. I would like to refer you to the article in pharmacological reviews by Serdar Bulun etal that deals with the aromatase enzyme and its production in explicit detail. I think it is a 2005 issue. Also refer to article by RJ Santen. A lot of work has been done in this regard.
Dear Danilo thanks alot for your interest .. for these side effects that therapy of breast cancer by anti estrogens may cause I was asking for the specific cells in breast secreting the aromatase enzyme .
Dear Neeta, thanks alot for your references .
Often the fibroblasts surrounding the tumor produce estrogens (via aromatase) that stimulate tumorgrowth through paracrine action. In turn, tumor cells secrete IL-6 and other factors that stimulate aromatase activity in the fibroblasts, thus creating a positive feedback loop.
Cancer-associated fibroblasts express aromatase, thereby converting androgen to estrogen, which promotes the breast cancer cell proliferation. The aromatase expression in breast cancer fibroblasts shows up-regulation due to the inflammatory cytokines such as PGE2, IL-6 and TNF-alpha secreted in a paracrine manner.
Article Aromatase inhibitors for breast cancer: Lessons from the laboratory.
its well known that sex steroids are involved in growth of breast cancers, and the great majority of breast carcinomas express estrogen, progesterone, and androgen receptors. recent study demonstrated that estrogen and androgen are locally produced in breast carcinoma tissue. enzymes related to intratumoral production of estrogen's (aromatase, 17b-hydroxysteroid dehydrogenase type1 andstroid sulfatase and androgens(takashi et al.,2005).
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