How to measure bacterial fitness for modelling evolution?

Hi, I would like to measure the fitness of bacterial species carrying antibiotic resistance genes (two genes in total) and model the evolution and spread of these two strains (with two different...

06 July 2018 6,839 2 View

What topics to study for learning molecular simulations relevant to biology?

Good day everyone! I am interested in learning molecular simulations of bio-molecules especially bacterial proteins. I have tried to watch/read a few lectures/articles regarding this. However, I...

05 June 2018 6,054 2 View

What force field should I select for protein - ligand complex?

Hi, I am planning to study the mechanism of drug efflux membrane protein using MD simulations. I have successfully docked the ligand. Now I would like to perform MD simulations on the protein....

02 March 2018 5,268 3 View

Are there any web-based MD simulation softwares? Can I use web-based MD simulation software for publishing my results?

Hi, I would like to run MD simulation of a membrane protein using GROMACS or NAMD. However, my institute does-not have high configuration systems, and I have no financial support for purchasing...

31 December 2017 7,337 7 View

Which processor is better for running MD simulations - i7 7700 or AMD Ryzen 1700X?

Hi all, I wish to purchase an assembled PC for running MD simulations myself. My specifications are: 8GB RAM, 1 TB ROM, NVIDIA M2000 GPU apart from all other general features. I was unable to...

10 November 2017 1,578 7 View

How to find gi identifier in BLASTp for submitting y model to PMDB? Any databases other than PMDB for submitting modelled proteins?

Dear all, I have modelled a drug efflux protein using ITASSER. I would like to upload the model in Protein Model Database (http://www.biocomputing.it/PMDB). The accession number is...

09 October 2017 1,829 3 View

How to define parameters for running a MD simulation?

I have been working on understanding the mechanism of efflux mediated drug resistance in bacteria. I was able to successfully model the protein using homology modelling and threading. Now I would...

07 August 2017 6,940 8 View

Generating random numbers for biological research

Hi..I would like to apply random sampling technique for the distribution of genes in a collection of bacterial samples. I would like to test finally 250 samples out of 500. Please suggest me a...

03 April 2017 5,354 3 View

How to choose the method of phylogenetic tree construction?

31 December 2016 6,137 5 View

How to perform in silico analysis of an enzyme's action on gram positive cell wall?

Hi, I wish to apply in silico methods for analysing the activity of a protein. the protein is actually an enzyme that destroys gram positive cell walls. I wish to model the effect of various...

11 December 2016 6,802 1 View

Could you recommend any books about Number Theory?

Beginner level books. High level books. Analytical Number Theory. Algebraic Number Theory. Combinatorical Number Theory. Books about partitions. Books about primes.

03 March 2021 7,174 5 View

What's the best way to measure growth rates in House sparrow chicks from day 2 to day 10?

What's the best way to measure growth rates in House sparrow chicks from day 2 to day 10? Since, the growth curve from day 2 to 10 won't be like the "Logistic curve" it might not follow logistic...

03 March 2021 1,401 3 View

After a reference from Int J Body Compos Res, can any body help?

Hi, I am after the reference below, my library says it cannot obtain a copy either locally or internationally, any help appreciated! Chris Wang ZM, Heshka S, Wielopolski L, Pi-Sunyer FX, Pierson...

03 March 2021 6,193 1 View

What techniques can I use to determine the miscibility of polymer blends?

The term miscibility refers to the single-phase state in thermodynamics. I do not mean the compatibility of different components. To determine the miscibility I know several techniques such as...

03 March 2021 4,107 4 View

Arena simulation - how do i model the following model in ARENA (see description) (new to ARENA)?

Hello, I'm fairly new to ARENA and I have the following problem: I have two queues in which, in each queue, a different order type arrives (both having an arrival rate of exponential 10). Order...

02 March 2021 2,431 3 View

How to repeat an operation on an atom selection for multiple times in PyMol?

Hi, I am trying to construct a multi-layer fibril structure from a single layer in PyMol by translating the layer along the fibril axis. For now, I am able to use the Translate command in PyMol...

02 March 2021 4,569 4 View

What analysis to choose with a large neste dataset and clearly skewed or kurtotic distributions?

Hello! I have a dataset of n=3000 nested within 8 countries with approximately 200 or 400 responses in each country. I originally planned to perform multilevel modelling with 4 dependent variables...

02 March 2021 6,865 1 View

Is there a powerful system for the security of the systems distributed on IoT systems?

Is there a powerful system for the security of the systems distributed on IoT systems?

02 March 2021 3,858 10 View

How Relativistic effects is one reason for lanthanide contraction?

The Lanthanide contraction which is the decrease in ionic radii of the elements in the lanthanide series from atomic number 57, lanthanum, to 71, lutetium, is due to poor shielding of the 4f...

01 March 2021 2,272 4 View

Shall I skip the measurement model in SmartPLS?

Hello everyone, I had run a mediation model in SmartPLS using questionnaires that were already validated among my statistical population. A professor who edited my paper -though she is not...

01 March 2021 3,052 3 View