14 Questions 34 Answers 0 Followers
Questions related from Sreeram Chandra Murthy Peela
Hi, I would like to measure the fitness of bacterial species carrying antibiotic resistance genes (two genes in total) and model the evolution and spread of these two strains (with two different...
07 July 2018 6,964 2 View
Good day everyone! I am interested in learning molecular simulations of bio-molecules especially bacterial proteins. I have tried to watch/read a few lectures/articles regarding this. However, I...
06 June 2018 6,143 2 View
Hi, I am planning to study the mechanism of drug efflux membrane protein using MD simulations. I have successfully docked the ligand. Now I would like to perform MD simulations on the protein....
03 March 2018 5,343 3 View
Hi, I would like to run MD simulation of a membrane protein using GROMACS or NAMD. However, my institute does-not have high configuration systems, and I have no financial support for purchasing...
01 January 2018 7,503 7 View
Hi all, I wish to purchase an assembled PC for running MD simulations myself. My specifications are: 8GB RAM, 1 TB ROM, NVIDIA M2000 GPU apart from all other general features. I was unable to...
11 November 2017 1,662 7 View
Dear all, I have modelled a drug efflux protein using ITASSER. I would like to upload the model in Protein Model Database (http://www.biocomputing.it/PMDB). The accession number is...
10 October 2017 1,921 3 View
I have been working on understanding the mechanism of efflux mediated drug resistance in bacteria. I was able to successfully model the protein using homology modelling and threading. Now I would...
08 August 2017 7,054 8 View
Hi..I would like to apply random sampling technique for the distribution of genes in a collection of bacterial samples. I would like to test finally 250 samples out of 500. Please suggest me a...
04 April 2017 5,420 3 View
Hi, I am trying to confirm the bacterial isolates by sequencing. I have targeted lytA gene in Streptococcus pneumoniae. I completed the alignment using CLUSTALW. Now I would like to analyse the...
01 January 2017 6,250 5 View
Hi, I wish to apply in silico methods for analysing the activity of a protein. the protein is actually an enzyme that destroys gram positive cell walls. I wish to model the effect of various...
12 December 2016 6,892 1 View
Hi I want to calculate the enzyme activities of a wild type (structure determined using x-ray crystallography) and a mutant protein (the structure of this protein was determined by homology...
09 September 2016 4,207 6 View
I am working on detection of Streptococcus pneumoniae in clinical samples like blood and CSF. I have been doing the assay based on the primers and probe recommended by CDC. However I reduced the...
08 August 2016 592 9 View
hi. i have been trying to run Modeller 9.16 to predict structure of the protein. I created the necessary files (scripts) based on the examples provided in the tutorial. I just kept the default...
06 June 2016 7,008 3 View
Please tell me the topics to study for Mathematical modelling for biological systems any researcher working on that in India or abroad.
05 May 2016 8,277 8 View
