The criteria to choose the best solvent for the bio extraction pharmaciutical processes:
Dear Baru Debtera Bejena your question is interesting but a bit too general to give you a detailed answer. It would be important to know what kind of compounds you want to extract. To give you some initial information, please check this closely related RG thread entitled "Which is the best solvent for herbal extraction?" which has already received 212 answers:
https://www.researchgate.net/post/Which_is_the_best_solvent_for_herbal_extraction
There is no general best solvent for the extraction of bioactive components. The solvent is always based upon the nature of compounds you want to isolate from the plant material. e.g. if you want to extract non-polar components like sterols or specifically, stigmasterol or sitosterol, you will prefer non-polar kind of solvents like hexane or its mixture with ethyl acetate according to the nature of the plant material.
Thus, you must first target the type of compounds, accordingly the type of solvent will be selected after following the polarity chart of the solvents.
Additionally, while selecting the the solvents for extraction, you must look into the accessibility and handling of the selected solvent.
Please look at the following below links which may help you in your analysis:
https://www.env.go.jp/en/chemi/pops/Appendix/04-GuideLine/04Chapter3.pdf
https://www.osti.gov/pages/servlets/purl/1356890
Thanks
Please look at the following below links which may help you in your analysis:
https://www.jocpr.com/articles/using-data-mining-and-uvvis-spectrophotometric-to-determine-the-content-of-bisphenol-a-in-plastics.pdf
https://en.cnki.com.cn/Article_en/CJFDTotal-FXSY201312014.htm
Thanks
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