Forgive me for being Naive.
I have read that the postprandial concentration normally doesn't go above 140mg/dl, anything above it is considered diabetic.
for instance:
https://care.diabetesjournals.org/content/24/4/775
Then why do researchers use very high glucose concentration like 16.5mM ( 300Mg/dl) or 25mM..approx 450mg/dl, in few of them i have even seen 55mM (1000mg/dl) to study diabetic mechanisms? does the glucose conc in diabetic individuals really go that high?
Heena Pahwa :
Glucose concentrations in people without diabetes can certainly exceed 140 mg/dl (7.8 mmol/l), depending on circumstances like meal intake. In a recent study we performed with subjects without diabetes, we found glucose concentrations could sometimes be as high as 200 mg/dl (11.1 mmol/l) ( https://ada.scientificposters.com/index.cfm?k=28sa79dr9i ). We performed a 75-gram oral glucose tolerance test (OGTT) with each subject to verify that the subjects did not have diabetes or increased fasting glucose or impaired glucose tolerance.
According to a WHO guideline, diabetes can be diagnosed in an OGTT if the fasting glucose level exceed 125 mg/dl (6.9 mmol/l) or if the 2-hour glucose level exceeds 200 mg/dl (11.1 mmol/l).
In other studies, in which subjects with type 1 diabetes participated, we have occasionally observed glucose concentrations exceeding 400 mg/dl (22.2 mmol/l). It has to be noted that recent recommendations on clinical targets for continuous glucose monitoring ( https://care.diabetesjournals.org/content/42/8/1593.long ) state that typical patients with type 1 diabetes should spend less than 25% of time at glucose concentations >180 mg/dl (10 mmol/l) and less than 5% of time at glucose concentrations >250 mg/dl (13.9 mmol/l).
This describes the clinical target if everything goes as planned. If, however, a diabetes patient forgets to deliver insulin or of their infusion set is damaged or occluded, and insulin delivery does not take place over a prolonged period, even higher glucose concentrations can occur.
In humans and in rodents such as the rat and laboratory mouse, the standard physiological parameters that are already known,
fasting glucose level of rat is below 100 mg/dl and glucose level
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