are there serum bio markers that we can depend on to evaluate the depression outcome in rat model of depression ?
Selection and dynamic metabolic response of rat biomarkers by metabonomics and multivariate statistical analysis combined with GC–MS.
doi: http://dx.doi.org/10.1016/j.pbb.2013.12.013
By Gao, Xiaoxia; Guo, Bingrong; Yang, Lan; Liu, Jiali; Zhang, Xiaoqin; Qin, Xuemei; Du, Guanhua
Pharmacology, Biochemistry and Behavior, Vol 117, Feb 2014, 85-91.
Early-life stress and antidepressants modulate peripheral biomarkers in a gene–environment rat model of depression.
doi: http://dx.doi.org/10.1016/j.pnpbp.2010.05.019
By Carboni, Lucia; Becchi, Serena; Piubelli, Chiara; Mallei, Alessandra; Giambelli, Roberto; Razzoli, Maria; Mathé, Aleksander A.; Popoli, Maurizio; Domenici, Enrico
Progress in Neuro-Psychopharmacology & Biological Psychiatry, Vol 34(6), Aug 16 , 2010, 1037-1048.
See the link below for some interesting recent work on tryptophan and kynurenine pathway and biomarkers.
http://www.sciencedirect.com/science/article/pii/S0092867414010496
I would think that elevated cortisol would be present.
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