What role does cytokine concentration play in the probability of cell death?

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20 hours? 24 hours?

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Is cancer cell motility in the early stages of cancer lower than in the advanced stage of cancer?

Is cancer cell motility in the early stages of cancer much lower than in the advanced stage of cancer? What is the reason?

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When a cancer treatment is applied and the cancer cells die, the space they occupied becomes vacant?

What happens exactly?

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Is there any technique for increasing the invasion potential of cells (by ignoring the contact inhibition mechanism) in in-vitro experiments?

It can be in 2d or 3d models (multicellular spheroids).

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Do conventional cancer treatments facilitate or stimulate the asymmetric divisions of cancer stem cells?

Is there any evidence of that?

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Is the motility of Cancer Stem Cells higher or lower than differentiated cancer cells?

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What is the state of the art in Differentiation Therapy with Cancer Stem Cells?

clinical trials or something else?

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Separation of organic acids-HPLC?

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Jacques Gilloteaux

I am not sure as I am not biochemist or toxicologist. Sorry.

Robert Kiss

You cannot "compute" such a complex and still not yet fully deciphered biological event.

As a researcher, I think that you will still look for a very long time for such an equation ...

Best regards

Robert

Yes I can see where you go. Of course LD50 /IC50 is the best way because indeed a value of cytokine(s) is complex, more than one product can be involved from cells and their created environment with the culture or treatment milieu.