From my understanding, Ceftazidime antibiotic inhibits the peptidoglycan synthesis process by binding to penicillin-binding protein. But in Aeromonas hydrophila I could not find any Penicillin-binding protein for molecular docking purposes as a comparison for my compound. I was wondering which specific penicillin-binding protein does ceftazidime binds to in Aeromonas hydrophila or does it simply bind to other proteins that eventually inhibit the synthesis of peptidoglycan? Can anyone please help me out? Thanks in advance
I can't say for Aeromonas hydrophila, but for E. coli the main essential target of ceftazidime is penicillin-binding protein 3 (PBP3), which is the product of the ftsI gene.
https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(15)30272-X/fulltext
@Hersh Maan. Thanks for the sharing. Any idea whats the PDB id for this two proteins? I wanted to do a molecular docking with this two proteins of interest. Thank you.
Aeromonas hydrophila does have the ftsI gene, encoding PBP3, which is the main target of ceftazidime in E. coli, as I mentioned previously. However, there does not appear to be a structure for this protein deposited. You could try to make a homology model using PBP3 structures from other organisms, if they are close enough in sequence. Aeromonas hydrophila PBP3 and E. coli PBP3 have about 52% sequence identity.
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