What percent of an average human cell's overall dry protein mass is not part of any cell membrane?

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Tausif Alam

Ideally, a literature survey may be quite useful....

Trevor Tanner

I've been able to track down the percent composition of lipids/proteins within membranes of different cell types:

http://cr.middlebury.edu/biology/labbook/diffusion/frap/membranes/chap1.htm

And overall macro composition percentages within different cell types:

Feijó Delgado, F., Cermak, N., Hecht, V. C., Son, S., Li, Y., Knudsen, S. M., … Manalis, S. R. (2013). Intracellular Water Exchange for Measuring the Dry Mass, Water Mass and Changes in Chemical Composition of Living Cells. PLoS ONE, 8(7). https://doi.org/10.1371/journal.pone.0067590

But nothing that definitively confirms intracellular protein mass composition...

Put the two together and you will have your estimates for intracellular proteins.

I wish it were so simple. The total absolute lipid contributions from the plasma membranes, nuclear envelope, endoplasmic reticulum, golgi complex, and mitochondrion's outer and inner membranes aren't really clear. Such wildly different ratios of protein/lipid ranging from .2-3.5x among these components are primarily why I was hoping for an expert opinion.