What is the recommended dosage of AS1842856 for intraperitoneal injection in rats?

2 weeks ago 0 3K Report

Currently, we plan to use AS1842856 administered via intraperitoneal injection to intervene in the FOXO1 pathway in a rat model of coronary heart disease.

In SD rat experiments, can AS1842856 (HY-100596, MCE) be administered via intraperitoneal injection?

If the rat weighs 500g, what is your recommended dosage (mg/kg/day) to effectively inhibit FOXO1 expression? Is it necessary to administer the injection in divided doses (e.g., once or twice daily)?

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