I'm trying to synthesize gold NPs inside bacterial cells (now I work with E.coli) and wondering about the permeability of the gold salt (HAuCl4) to reach the periplasmic space.
Thanks.
Information relating to the effect and mechanism of action of gold salts on acute and chronic inflammatory processes has been reviewed. Gold salts are effective in suppressing various aspects of the acute inflammatory process although large gaps exist in the knowledge of the mechanisms involved. Available evidence indicates that gold salts affect many biochemical pathways and that interaction with enzymes plays a major role in their pharmacology. Because they are more difficult to investigate, the action of gold salts on various important aspects of chronic inflammation have not yet received much attention.
@saba a. Hussien
Thanks for the answer but unfortunately it doesn't refer to my question :/
yes it will penetrate the periplasmic space which one of the feature of gm negative bacteria such as E.coli as it has thin outer layer and your gold salts are in nanometric range it will penetrate the outer cell as well as periplasmic space .
here the permeability of cell is major factor
Traci L Testerman Thank you so much for your interesting comment. These mechanisms are really interesting and could be helpful for my project. Cheers!
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