Specifically, 1. are sailvary assays for cortisol and testosterone the best measure? Or is a urine estimate better? 2. How useful is urinary SHIAA as a measure of central serotonin levels/function?
Dear John,
Check these papers out if they give you any idea:
Article Salivary cortisol in preterm infants: Validation of a simple...
Article Efficacy of secretin for the treatment of autism
Article Antagonism of fenfluramine-induced hyperthermia: A measure o...
Article A clinical study of the efficacy of a single session of indi...
Urinary 5HIAA measures serotonin synthesis outside the brain, mainly in the intestine. There are two possible ways to measure the rate of serotonin synthesis in human brain. The first is measuring 5HIAA in the cerebrospinal fluid, a method that has been used for about 50 years. The second method is positron emission tomography using alpha-[11C]methyl-L-tryptophan. Unfortunately neither method is easy to do.
Article Differences between males and females in rates of serotonin ...
Article Monoamine metabolites in lumbar CSF: The question of their o...
Dear John,
While steroid salivary assaying is quite easy and popular, there are a few caveats. Please see Article Steroid Analysis in Saliva: An overview
andArticle Validating the salivary testosterone and Cortisol concentrat...
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