Many methods were used to induce bone by the use of PRP but the exact mechanism still unclear.
Forgive me, because actually the latest articles I've read on JOMI, JCP, JP indicated that PRP has no effect on osteogenesis either with in defected alveolar bone by debridement alone or with combination of regenerative bone procedures plus by using DFDBA, or with GBR or membranes, compare with all above mentioned without PRP, however the PRP doesn't show any promise in bone regenerative procedures, but studies showed that PRP contains some amounts of BMP2 and growth factors which still can not be proven to be replaced for the site of defected bone as by proper standard flap and debridement and inducing the proper vascularity of field of surgery if that correctly done. For short, PRP is not useful for new bone formation at least in alveolar bone.
To my best knowledge PRP application for new bone formation is promising,but not entirely proven. You may view the publication of Griffin XL et al. The use of P R P in the promotion of bone healing: a systematic review. Injury. 40,2, 2009, 158-62
With all due my respect to DR PANAYOT opinion, clinical studies of PRP is insignificant for (bone induction, bone conduction or even bone formation).. in one of the recent randomized clinical studies, which done In a 36-month extension study of a multicenter, randomized, controlled clinical trial on evaluating the effect and long-term stability of PDGF-BB treatment in 135 patients with localized severe periodontal osseous defects. Platelet-Derived Growth Factor (Recombinant human platelet-derived growth factor -rhPDGF) promoted periodontal regeneration in localized osseos defects "not PRP"! since it is not the PRP which DR IBRAHIM SAEED was asking about it's mechanism of action, but rhPDGF which was safe and effective for the treatment of periodontal defects.
Obviously again PDGF-BB (not PRP) in a synthetic scaffold matrix promotes long-term stable clinical and radiographic improvements as measured by composite outcomes for CAL gain and LBG for patients possessing localized periodontal defects (ClinicalTrials.gov no. CT01530126). J Periodontol 2013;84:456-464.
Probably the Main Question at first place was incomplete,since DR IBRAHIM SAEED said: Many methods were used to induce bone by the use of PRP but the exact mechanism still unclear...
As my clinical experience, aside the inconvenience of PRP procedures to the patient and the additional chair time and cost of PRP procedures plus the protocol of infection control which should be highly followed during blood taking, centrifuge,... for collecting PRP, during the time of main osseous surgery will be much more sensitive and needs alot of operators dexterity which makes the whole scenario questionable even during the mucocutaneous flap procedures such as tunneling techniques, or connective tissue grafting and periodontal flaps
However it is more inconvenient and questionable during bone regenerative procedures such as ridge augmentation, or to be used with GBR for osseous defect reconstructions.
Thanks Sir for correcting me, I was only addressing my personal point of view.
Thanks a lot for Dr. Hamid and Dr.Panayot for their information about PRP. Although Dr. Hamid had different idea about PRP I think there is a place for this material to induce new bone formation.
In relation to the point being debated, i.e. whether PRP has a role in new bone formation, I would like to draw the attention to the newer generation of platelet-derived materials, PRF or Platelet-rich-fibrin, introduced by Choukroun et al. There have been many reports of the usefulness of PRF in regenerative procedures including bone, periodontal ligament and pulp. The mechanism is best described in a series of articles by Dohan et al in OOOE journal. A simple google search can gain you access to the relevant info.
Thank you
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