Why are the biocomaptible iron oxide nanoparticles less toxic when compared to the bare nanoparticle ?
what is their mode of internalisation?
Coated IONPs - internalised (phagocytosis, macropinocytosis, caveolate mediated, clathrin mediated), move towards endosomes (early) - then late endosome - lysosomes and then - Mitochondria
is this pathway right?
Dear Purva:
Based on results of our studying pulmonary macrophages from bronchoalveolar lavage fluid obtained 24 hrs after intratracheal instillation of different metallic nanoparticles (NP) beginning from nano-iron (II, III) oxide (magnetite), with the help of optical, transmission еlectron and semicontact atomic force microscopy, I am convinced that for these cells active endocytosis is the main mechanism of NP's internalisation. You may find several relevant publications in my ResGate profile ("contributions') - for instance, Experimental estimates of the toxicity of iron oxide Fe3O4 (magnetite) nanoparticles.
Boris Katsnelson, L.I.Privalova, T.D.Degtya, M.P.Sutunkova, I.A. Minigalieva, et al
Central European Journal of Occupational and Environmental Medicine. 01/2010; 16(1-2):47-64.
As to why coating of any NPwith any biocompatible matter makes it less cytotoxic, honestly, I fail to see anytning strange and needing explanation in such a phenomenon, biocompatibility being the key word.
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